| Pair Name | Alpha-Mangostin, Tamoxifen | ||
| Phytochemical Name | Alpha-Mangostin (PubChem CID: 5281650 ) | ||
| Anticancer drug Name | Tamoxifen (PubChem CID: 2733526 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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| Pair Name | Alpha-Mangostin, Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | KCNH1 | hsa3756 |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| T-47D | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0553 | |
| Royan N30 | Healthy | Mus musculus (Mouse) | CVCL_9414 | |
| Result | This study establishes the benefits of incorporating AM as a co-adjuvant for first-line ER+ breast cancer therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhancing Tamoxifen Therapy with α-Mangostin: Synergistic Antiproliferative Effects on Breast Cancer Cells and Potential Reduced Endometrial Impact. Pharmaceuticals (Basel). 2023 Nov 8;16(11):1576. doi: 10.3390/ph16111576. | Click |
